TENEX may refer to:
- TOPS-20 operating system
- Tekhsnabexport, a Russian company specializing in export of nuclear materials
- TENEX Computer Express, a popular computer mail order company based in northern Indiana in the 80s and 90s.
- Tenex is also a brand name for guanfacine, an antihypertensive medication that can be used to control high blood pressure and nervous disorders as in muscle twitches.
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